研究業績

ナノ医科学

ナノテクノロジーは、既存の方法とは一線を画した原子・分子レベルの制御技術です。 理工学ナノテク技術と連携し、がんのメカニズム解明から創薬、病理診断、精細な外科手術まで多岐に渡る研究を行っています。

  1. 1.Gonda K, Watanabe M, Tada H, Miyashita M, Takahashi-Aoyama Y, Kamei T, Ishida T, Usami S, Hirakawa H, Kakugawa Y, Hamanaka Y, Yoshida R, Furuta A, Okada H, Goda H, Negishi H, Takanashi K, Takahashi M, Ozaki Y, Yoshihara Y, Nakano Y, Ohuchi N. Quantitative diagnostic imaging of cancer tissues by using phosphor-integrated dots with ultra-high brightness. Sci Rep. 2017 Aug 8;7(1):7509. doi: 10.1038/s41598-017-06534-z.
  2. 2.Nakagawa T, Gonda K, Kamei T, Cong L, Hamada Y, Kitamura N, Tada H, Ishida T, Aimiya T, Furusawa N, Nakano Y, Ohuchi N. X-ray computed tomography imaging of a tumor with high sensitivity using gold nanoparticles conjugated to a cancer-specific antibody via polyethylene glycol chains on their surface. Sci Technol Adv Mater. 2016 Jul 26;17(1):387-397. eCollection 2016.
  3. 3.Miyashita M, Gonda K, Tada H, Watanabe M, Kitamura N, Kamei T, Sasano H, Ishida T, Ohuchi N. Quantitative diagnosis of HER2 protein expressing breast cancer by single-particle quantum dot imaging. Cancer Med. 2016 Oct;5(10):2813-2824. doi: 10.1002/cam4.898. Epub 2016 Sep 26.
  4. 4.Gonda K, Miyashita M, Higuchi H, Tada H, Watanabe TM, Watanabe M, Ishida T, Ohuchi N. Predictive diagnosis of the risk of breast cancer recurrence after surgery by single-particle quantum dot imaging. Sci Rep. 2015 Sep 22;5:14322. doi: 10.1038/srep14322.
  5. 5.Sakurai Y, Tada H, Gonda K, Takeda M, Cong L, Amari M, Kobayashi Y, Watanabe M, Ishida T, Ohuchi N. Development of silica-coated silver iodide nanoparticles and their biodistribution. Tohoku J Exp Med. 2012;228(4):317-23.
  6. 6.Gonda K, Miyashita M, Watanabe M, Takahashi Y, Goda H, Okada H, Nakano Y, Tada H, Amari M, Ohuchi N. Development of a quantitative diagnostic method of estrogen receptor expression levels by immunohistochemistry using organic fluorescent material-assembled nanoparticles. Biochem Biophys Res Commun. 2012 Sep 28;426(3):409-14.
  7. 7.Hamada Y, Gonda K, Takeda M, Sato A, Watanabe M, Yambe T, Satomi S, Ohuchi N. In vivo imaging of the molecular distribution of the VEGF receptor during angiogenesis in a mouse model of ischemia. Blood. 2011 Sep 29;118(13):e93-e100.
  8. 8.Cong L, Takeda M, Hamanaka Y, Gonda K, Watanabe M, Kumasaka M, Kobayashi Y, Kobayashi M, Ohuchi N. Uniform silica coated fluorescent nanoparticles: synthetic method, improved light stability and application to visualize lymph network tracer. PLoS One. 2010 Oct 18;5(10):e13167.
  9. 9.Hikage M, Gonda K, Takeda M, Kamei T, Kobayashi M, Kumasaka M, Watanabe M, Satomi S, Ohuchi N. Nano-imaging of the lymph network structure with quantum dots. Nanotechnology. 2010 May 7;21(18):185103.
  10. 10.Kawai M, Higuchi H, Takeda M, Kobayashi Y, Ohuchi N. Dynamics of different-sized solid-state nanocrystals as tracers for a drug-delivery system in the interstitium of a human tumor xenograft. Breast Cancer Res. 2009;11(4):R43.
  11. 11.Kohno M, Takeda M, Niwano Y, Saito R, Emoto N, Tada M, Kanazawa T, Ohuchi N, Yamada R. Early diagnosis of cancer by detecting the chemiluminescence of hematoporphyrins in peripheral blood lymphocytes. Tohoku J Exp Med. 2008 Sep;216(1):47-52.
  12. 12.Takeda M, Gonda K, Higuchi H, Ohuchi N. [In vivo single molecular fluorescence imaging for analysis of pharmacokinetics]. Gan To Kagaku Ryoho. 2008 Aug;35(8):1277-80. Japanese.
  13. 13.Takeda M, Tada H, Higuchi H, Kobayashi Y, Kobayashi M, Sakurai Y, Ishida T, Ohuchi N. In vivo single molecular imaging and sentinel node navigation by nanotechnology for molecular targeting drug-delivery systems and tailor-made medicine. Breast Cancer. 2008;15(2):145-52.
  14. 14.Park YS, Dmytruk A, Dmitruk I, Yasuto N, Kasuya A, Takeda M, Ohuchi N. Aqueous-phase synthesis of ultra-stable small CdSe nanoparticles. J Nanosci Nanotechnol. 2007 Nov;7(11):3750-3.
  15. 15.Tada H, Higuchi H, Wanatabe TM, Ohuchi N. In vivo real-time tracking of single quantum dots conjugated with monoclonal anti-HER2 antibody in tumors of mice. Cancer Res. 2007 Feb 1;67(3):1138-44.
  16. 16.Park YS, Liz-Marzan LM, Kasuya A, Kobayashi Y, Nagao D, Konno M, Mamykin S, Dmytruk A, Takeda M, Ohuchi N. X-ray absorption of gold nanoparticles with thin silica shell. J Nanosci Nanotechnol. 2006 Nov;6(11):3503-6.
  17. 17.Li-Shishido S, Watanabe TM, Tada H, Higuchi H, Ohuchi N. Reduction in nonfluorescence state of quantum dots on an immunofluorescence staining. Biochem Biophys Res Commun. 2006 Dec 8;351(1):7-13.
  18. 18.Nakajima M, Takeda M, Kobayashi M, Suzuki S, Ohuchi N. Nano-sized fluorescent particles as new tracers for sentinel node detection: experimental model for decision of appropriate size and wavelength. Cancer Sci. 2005 Jun;96(6):353-6.
  19. 19.Takeda M, Kobayashi M, Takayama M, Suzuki S, Ishida T, Ohnuki K, Moriya T, Ohuchi N. Biophoton detection as a novel technique for cancer imaging. Cancer Sci. 2004 Aug;95(8):656-61.

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